Title :
Interactive DNA sequence and structure design for DNA nanoapplications
Author :
Zhang, Mingjun ; Sabharwal, Chaman L. ; Tao, WeiMin ; Tarn, Tzyh-Jong ; Xi, Ning ; Li, Guangyong
Author_Institution :
Life Sci. & Chem. Anal. Div., Agilent Technol., Palo Alto, CA, USA
Abstract :
DNA sequence and structure design is very important for DNA nanoapplications. A computer-aided design tool is needed for exploring DNA sequence and structure of interests before experimental synthesis, which is a time- and labor-consuming process. In this paper, an interactive DNA sequence and structure design software tool called DNA shop is proposed and implemented. The visualization tool can generate DNA structures by specifying, selecting, and moving DNA sequences around and display corresponding structures. Using the tool, DNA sequence and structure can be visually inspected in three-dimensional space before experimental studies.
Keywords :
DNA; biology computing; biotechnology; data visualisation; molecular biophysics; molecular configurations; nanotechnology; DNA nanoapplications; DNA shop; DNA structure design; computer-aided design tool; interactive DNA sequence; visualization tool; Assembly; Automation; Computer displays; DNA computing; Nanoscale devices; Nanotechnology; Self-assembly; Sequences; Space technology; Visualization; DNA computation; DNA machine; DNA nanotechnology; interactive design; visualization; Algorithms; Base Sequence; Computer Graphics; Computer Simulation; Computer-Aided Design; DNA; DNA Probes; Imaging, Three-Dimensional; Models, Chemical; Models, Molecular; Molecular Sequence Data; Nanotechnology; Nucleic Acid Conformation; Sequence Analysis, DNA; Software; User-Computer Interface;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2004.837918
