Title :
Development of a Photoacoustic, Ultrasound and Fluorescence Imaging Catheter for the Study of Atherosclerotic Plaque
Author :
Abran, Maxime ; Cloutier, Guy ; Cardinal, Marie-Helene Roy ; Chayer, Boris ; Tardif, Jean-Claude ; Lesage, Frederic
Author_Institution :
Dept. de Genie Electr., Ecole Polytech. de Montreal, Montreal, QC, Canada
Abstract :
Atherosclerotic cardiovascular diseases are a major cause of death in industrialized countries. Molecular imaging modalities are increasingly recognized to be a promising avenue towards improved diagnosis and for the evaluation of new drug therapies. In this work, we present an acquisition system and associated catheter enabling simultaneous photoacoustic, ultrasound and fluorescence imaging of arteries designed for in vivo imaging. The catheter performance is evaluated in tissue-mimicking phantoms. Simultaneous imaging with three modalities is demonstrated at frame rates of 30 images per second for ultrasound and fluorescence and 1 image per 13 seconds for photoacoustic. Acquired radio-frequency ultrasound data could be processed to obtain radial strain elastograms. With motorized pullback, 3D imaging of phantoms was performed using the three modalities.
Keywords :
biomedical optical imaging; biomedical ultrasonics; blood vessels; cardiovascular system; catheters; data acquisition; diseases; drugs; fluorescence; phantoms; photoacoustic effect; arteries; atherosclerotic cardiovascular diseases; atherosclerotic plaque; drug therapies; fluorescence imaging catheter; in vivo imaging; molecular imaging modalities; motorized pullback; patient diagnosis; photoacoustic imaging catheter; radial strain elastograms; radiofrequency ultrasound data acquisition system; tissue-mimicking phantoms; ultrasound imaging catheter; Catheters; Imaging phantoms; Optical imaging; Phantoms; Three-dimensional displays; Ultrasonic imaging; Biomedical electronics; biomedical optical imaging; catheters; fluorescence; molecular imaging; phantoms; photoacoustic effects; ultrasonic imaging;
Journal_Title :
Biomedical Circuits and Systems, IEEE Transactions on
DOI :
10.1109/TBCAS.2014.2360560