Title :
Immunology and disease control: a systems approach
Author :
Asachenkov, Alexander L. ; Marchuk, Gurij I. ; Mohler, Ronald R. ; Zuev, Sergei M.
Author_Institution :
Dept. of Syst. & Decision Sci., Int. Inst. for Appl. Syst. Anal., Laxenburg, Austria
Abstract :
The application of system theory (or more precisely, differential equations) to immunology and disease, in general, is presented here. Particular results from U.S.-Russian research collaboration depict the potential role of such systematic analysis for more effective health care and disease control. In particular, some emphasis is given to control of influenza. After a brief systematic overview of immunology, a simple infectious disease model is developed to explain four basic forms of disease: subclinical, acute, lethal and chronic. Then, disease treatment is studied.
Keywords :
biocontrol; differential equations; physiological models; U.S.-Russian research collaboration; acute disease; chronic disease; disease control; disease treatment; effective health care; immunology; influenza control; lethal disease; simple infectious disease model; subclinical disease; Cells (biology); Control systems; Differential equations; Diseases; Immune system; Influenza; Medical services; Pathogens; Plasmas; Viruses (medical); Acute Disease; Chronic Disease; Communicable Diseases; Computer Simulation; Humans; Influenza, Human; Models, Biological; Systems Theory;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
