This paper discusses the global stability of a nonlinear dynamical system

in which

is a locally Lipschitz continuous off-diagonally monotone function and

. Two results are proved: 1) if

is piecewise-linear function and if

is an

-function, then a unique equilibrium point exists and it is globally asymptotically stable; 2) if

is a nonlinear function with separate variables in the sense that

is given by

for all

, and if

is an

-function satisfying

for some nonnegative vector

, then

is globally asymptotically stable. These results are applied to the stability analyses of a large scale composite system and a compartmental system.