BioXyce: an engineering platform for the study of cellular systems

Author

May, Elebeoba E. ; Schiek, R.L.

Author_Institution

Discrete Math. & Complex Syst. Dept., Sandia Nat. Labs., Albuquerque, NM

Volume

3

Issue

2

fYear

2009

fDate

3/1/2009 12:00:00 AM

Firstpage

77

Lastpage

89

Abstract

Researchers use constructs from the field of electrical engineering for the modelling and analysis of biological systems, but few exploit parallels between electrical and biological circuits for simulation purposes. The authors discuss the development of BioXyce, a circuit-based biological simulation platform that uses Xycetrade, a large-scale electrical circuit simulator, as its simulation engine. BioXyce is capable of simulating whole-cell and multicellular systems. Simulation results for the central metabolism in Escherichia coli K12 and cellular differentiation in Drosophila sp. are presented.

Keywords

biochemistry; bioelectric phenomena; biology computing; biomolecular electronics; cellular biophysics; logic circuits; microorganisms; BioXyce; Drosophila sp; Escherichia coli K12; biochemical reactions; cellular differentiation; cellular systems; central metabolism; circuit-based biological simulation platform; large-scale electrical circuit simulator; multicellular systems; whole-cell systems;

fLanguage

English

Journal_Title

Systems Biology, IET

Publisher

iet

ISSN

1751-8849

Type

jour

DOI

10.1049/iet-syb.2007.0086

Filename

4801438