In vivo and in vitro investigation of photosensitizer-adsorbed superparamagnetic nanoparticles for photodynamic therapy

Author

Park, S.I. ; Lim, J.H. ; Kim, J.H. ; Yun, H.I. ; Kim, C.O.

Author_Institution

Dept. of Mater. Eng., Chungnam Nat. Univ., Daejeon, South Korea

Volume

41

Issue

10

fYear

2005

Firstpage

4111

Lastpage

4113

Abstract

Superparamagnetic particles of Fe₃O₄ were nanometrically synthesized by coprecipitation. Hematoporphyrin (HP) and 5-aminolevulinic acid (ALA) were used as photosensitizers, which were adsorbed on magnetic particles. The adsorption rates of HP and ALA were observed to 2.0% and 12.5% by UV spectrometry and the pico-tag method, respectively. The toxicity of the magnetic fluids was estimated using Sprague-Dawley rats. The photodynamic effect of the photosensitizer-adsorbed magnetic fluids was examined with a human lung cancer cell, for which the light doses were applied to 400 mJ/cm³.

Keywords

cancer; cellular effects of radiation; iron compounds; magnetic fluids; magnetic particles; nanoparticles; paramagnetic materials; photodynamic therapy; precipitation; ultraviolet spectrometers; 5-aminole-vulinic acid; Fe₃O₄; Sprague-Dawley rats; UV spectrometry; cancer cell; coprecipitation; hematoporphyrin; magnetic fluids toxicity; magnetic particle; photodynamic effect; photodynamic therapy; photosensitizer; pico-tag method; superparamagnetic nanoparticles; Humans; In vitro; In vivo; Iron; Magnetic liquids; Magnetic particles; Medical treatment; Nanoparticles; Rats; Spectroscopy; Cancer cell; in vitro; in vivo; magnetic particle; photodynamic therapy; photosensitizer;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2005.854462

Filename

1519552