Title :
Surface modification of hydrophobic iron oxide nanoparticles for clinical applications
Author :
Woo, Kyoungja ; Hong, Jangwon
Author_Institution :
Nano-Mater. Res. Center, Korea Adv. Energy Res. Inst., Seoul, South Korea
Abstract :
Monodisperse superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by thermal decomposition of Fe(CO)5 and by consecutive aeration in organic medium. The resultant hydrophobic SPION surface was modified to be hydrophilic via Fe-S covalent bond with bi-functional 3-mercaptopropionic acid and then, the terminal carboxylic acid group was esterified with dextran for biocompatibility. Analysis by water dispersity, transmission electron microscopy, X-ray diffraction, and Fourier transformed infrared spectroscopy are reported.
Keywords :
Fourier transform spectroscopy; X-ray diffraction; iron compounds; magnetic materials; nanoparticles; pyrolysis; superparamagnetism; surface morphology; transmission electron microscopy; 3-mercaptopropionic acid; Fe(CO)5; Fourier transformed infrared spectroscopy; X-ray diffraction; biocompatibility; carboxylic acid; clinical applications; hydrophobic iron oxide nanoparticles; monodisperse superparamagnetic iron oxide nanoparticles; surface modification; thermal decomposition; transmission electron microscopy; water dispersity; Bonding; Electrons; Iron; Magnetic separation; Nanoparticles; Nitrogen; Polymers; Protection; Temperature; Thermal decomposition; Iron oxide; nanoparticles; superparamagnetic; surface modification;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2005.855343
