Novel superparamagnetic Core(Shell) nanoparticles for magnetic targeted drug delivery and hyperthermia treatment

Author

Gangopadhyay, Palash ; Gallet, Sébastien ; Franz, Edith ; Persoons, André ; Verbiest, Thierry

Author_Institution

Dept. of Chem., Catholic Univ. of Leuven, Heverlee, Belgium

Volume

41

Issue

10

fYear

2005

Firstpage

4194

Lastpage

4196

Abstract

Superparamagnetic γ-Fe₂O₃(Au) core(shell) nanoparticles with narrow size distribution and different shell thicknesses are synthesized. On conjugation with serum albumin, this set of particles forms an ideal candidate to be used in magnetic targeted drug delivery and hyperthermia treatment. In this contribution, the synthesis and characterizations of their size, optical, and magnetic properties are reported. It has also been shown that using different shell thicknesses, it is possible to tune not only the plasmon response of the gold shell but also the magnetic property of these superparamagnetic nanoparticles.

Keywords

drug delivery systems; hyperthermia; iron compounds; magnetic particles; nanoparticles; patient treatment; superparamagnetism; Fe₂O₃Au; core/shell nanoparticles; hyperthermia treatment; magnetic properties; magnetic targeted drug delivery; optical properties; plasmon response; serum albumin; shell thickness; size characterization; superparamagnetic nanoparticles; Cancer; Drug delivery; Gold; Hyperthermia; Magnetic cores; Magnetic materials; Magnetic properties; Nanoparticles; Plasmons; Targeted drug delivery; Core(shell) nanoparticles; hyperthermia; maghemite (gold); magnetic targeted drug delivery;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2005.854805

Filename

1519578