Detection of Digitalis Toxicity by Computerized Electrocardiogram Monitoring

A new ECG monitoring technique is described which can detect the condition of digitalis toxicity prior to the onset of arrhythmias. The technique is based on experiments with mice in which digitalis toxicity was induced by the administration of the cardiac glycoside, ouabain. Results are shown in which spreading of the QRS complex is a consistent precursor of premature ventricular contractions and ventricular fibrillation. Both high and low dose studies are described.