Title :
An Objective Method to Identify Inhomogeneity in Washout Curves
Author :
Aaazro, Steven H. ; Stratton, Howard H. ; Newell, Jonathan C. ; Paloski, William H. ; Smith, Edward J. ; Dutton, Robert E.
Author_Institution :
General Electric, Corporate Research and Development
Abstract :
A statistical screening test has been developed for processing washout data to choose the best model for these data. A choice is made between a linear single-compartment model and nonlinear multi-compartment model. The screen is expressed as a test of a null hypothesis Ho, using a likelihood ratio test.
Keywords :
Biological system modeling; Least squares methods; Linear regression; Lungs; Newton method; Nitrogen; Noise measurement; Recursive estimation; Spline; Testing; Biological Transport; Humans; Mathematics; Metabolism; Models, Biological; Monte Carlo Method; Nitrogen; Respiration;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.1981.324856
