Long-Term Neuroelectric Signal Recording from Severed Nerves

Author

De Luca, Carlo J. ; Gilmore, L. Donald ; Bloom, L.Jack ; Thomson, Sandra J. ; Cudworth, Allen L. ; Glimcher, Melvin J.

Author_Institution

Department of Orthopaedic Surgery, Children´´s Hospital Medical Center, Harvard Medical School, Boston, MA 02115, and the Liberty Mutual Research Center

Issue

6

fYear

1982

fDate

6/1/1982 12:00:00 AM

Firstpage

393

Lastpage

403

Abstract

Six recording electrode units were implanted around the severed sciatic nerves of rabbits immediately after an axotomy was performed. Voluntary and involuntary motor neuroelectric signals (including individual action potentials) were recorded from the surface of the severed nerve for as long as 142 days after implantation, the average duration being 64 days. In order to study the course of the limited duration of the signal detection, a stimulation electrode was implanted around the sciatic nerve proximal to the lesion; evoked neuroelectric signals were recorded throughout the length of the experiment. The impedance of the recording electrode was also measured throughout the length of the experiment. The behavior of the above parameters, combined with histological observations, indicated that nerve degeneration accounted for the deterioration of signal detection.

Keywords

Electrodes; Hospitals; Impedance measurement; Length measurement; Lesions; Motion control; Orthopedic surgery; Pediatrics; Rabbits; Signal detection; Action Potentials; Animals; Electrodes, Implanted; Electronics, Medical; Evoked Potentials; Nerve Degeneration; Rabbits; Sciatic Nerve;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.1982.324953

Filename

4121435