DocumentCode
1215363
Title
Is it Possible to Analyze DNA and Protein Sequences by the Methods of Digital Signal Processing?
Author
Veljkovic, V. ; Cosic, I. ; Dimitrijevic ; Lalovic, D.
Author_Institution
Laboratory for Theoretical Physics, Boris Kidri¿Institute of Nuclear Sciences
Issue
5
fYear
1985
fDate
5/1/1985 12:00:00 AM
Firstpage
337
Lastpage
341
Abstract
Informational content of linear macromolecules (DNA, RNA, and proteins) is analyzed by the method of digital signal processing. Each element (amino acid or nucleotide) of macromolecules is represented by the corresponding value of electron-ion interaction potential. This numerical representation of the primary structure of macromolecules is subjected to digital signal processing in order to extract the information corresponding to biological function. It is shown that the multiple cross spectrum of functionally related sequences exhibits significant peak frequencies. In the case of functionally unrelated sequences such peaks were not found. Peak frequencies are different for different biological functions. Based on this, we conjecture that the peak frequencies in the multiple cross spectrum of sequences with the same boilogical function are related to this biological function.
Keywords
Amino acids; Charge carrier processes; DNA; Digital signal processing; Frequency; Information analysis; Proteins; RNA; Sequences; Signal analysis; Amino Acid Sequence; Base Sequence; Computers; DNA; Humans; Mathematics; RNA;
fLanguage
English
Journal_Title
Biomedical Engineering, IEEE Transactions on
Publisher
ieee
ISSN
0018-9294
Type
jour
DOI
10.1109/TBME.1985.325549
Filename
4122061
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