• DocumentCode
    1215363
  • Title

    Is it Possible to Analyze DNA and Protein Sequences by the Methods of Digital Signal Processing?

  • Author

    Veljkovic, V. ; Cosic, I. ; Dimitrijevic ; Lalovic, D.

  • Author_Institution
    Laboratory for Theoretical Physics, Boris Kidri¿Institute of Nuclear Sciences
  • Issue
    5
  • fYear
    1985
  • fDate
    5/1/1985 12:00:00 AM
  • Firstpage
    337
  • Lastpage
    341
  • Abstract
    Informational content of linear macromolecules (DNA, RNA, and proteins) is analyzed by the method of digital signal processing. Each element (amino acid or nucleotide) of macromolecules is represented by the corresponding value of electron-ion interaction potential. This numerical representation of the primary structure of macromolecules is subjected to digital signal processing in order to extract the information corresponding to biological function. It is shown that the multiple cross spectrum of functionally related sequences exhibits significant peak frequencies. In the case of functionally unrelated sequences such peaks were not found. Peak frequencies are different for different biological functions. Based on this, we conjecture that the peak frequencies in the multiple cross spectrum of sequences with the same boilogical function are related to this biological function.
  • Keywords
    Amino acids; Charge carrier processes; DNA; Digital signal processing; Frequency; Information analysis; Proteins; RNA; Sequences; Signal analysis; Amino Acid Sequence; Base Sequence; Computers; DNA; Humans; Mathematics; RNA;
  • fLanguage
    English
  • Journal_Title
    Biomedical Engineering, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    0018-9294
  • Type

    jour

  • DOI
    10.1109/TBME.1985.325549
  • Filename
    4122061