A Study of Magnetic Drug Delivery System Using Bulk High Temperature Superconducting Magnet

Author

Nishijima, Shigehiro ; Takeda, Shin-Ichi ; Mishima, Fumihito ; Tabata, Yasuhiko ; Yamamoto, Masaya ; Joh, Jun-ichiro ; Iseki, Hiroshi ; Muragaki, Yoshihiro ; Sasaki, Akira ; Jun, Kubota ; Saho, Norihide

Author_Institution

Div. of Sustainable Energy & Environ. Eng., Osaka Univ., Suita

Volume

18

Issue

2

fYear

2008

fDate

6/1/2008 12:00:00 AM

Firstpage

874

Lastpage

877

Abstract

A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

Keywords

biomagnetism; blood vessels; drug delivery systems; ferromagnetic materials; high-temperature superconductors; permanent magnets; superconducting magnets; blood vessel; distance 25 mm; drug navigation probability; ferromagnetic particles; high temperature superconducting magnet; magnetic drug delivery system; magnetic flux density 4.5 T; magnetic seeded drug; Bulk high temperature superconductor; magnetic drug delivery system; magnetic seeded drug; nano-sized particle; navigation of drag;

fLanguage

English

Journal_Title

Applied Superconductivity, IEEE Transactions on

Publisher

ieee

ISSN

1051-8223

Type

jour

DOI

10.1109/TASC.2008.921967

Filename

4517321