Title :
A Distributed Model of Iron Kinetics for Clinical Assessment of Normal-Abnormal Erythropoietic Activity
Author :
Franzone, Piero Colli ; Stefanelli, Mario ; Viganotti, Carlo
Author_Institution :
National Research Council, Laboratorio di Analisi Numerica del Consiglio Nazionale della Richerche, Pavia, Italy, and the School of Engineering, University of Pavia
Abstract :
The use of mathematical models of iron metabolism has been recognized as an essential tool for analyzing ferrokinetic data. Multicompartment models, however, did not make it possible to describe marrow iron kinetics, taking into account that marrow erythroid cells uptake iron from the plasma according to their maturity.
Keywords :
Biochemistry; Biomedical engineering; Blood; Bone diseases; Cells (biology); Councils; Iron; Kinetic theory; Mathematical model; Parameter estimation; Anemia; Bone Marrow; Erythrocytes; Erythropoiesis; Heme; Humans; Iron; Kinetics; Models, Biological;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.1979.326447
