Design and Evaluation of Magnetic Fields for Nanoparticle Drug Targeting in Cancer

Author

Gleich, Bernhard ; Hellwig, Nicole ; Bridell, Hanna ; Jurgons, Roland ; Seliger, Christian ; Alexiou, Christoph ; Wolf, Bernhard ; Weyh, Thomas

Author_Institution

Heinz Nixdorf-Lehrstuhl fur Medizinische Elektron., Technischen Univ. Munchen, Munich

Volume

6

Issue

2

fYear

2007

fDate

3/1/2007 12:00:00 AM

Firstpage

164

Lastpage

170

Abstract

The retention of superparamagnetic nanoparticles under the influence of a high-gradient magnetic field was investigated. A simulation algorithm for prediction of the particle´s trajectories and, therefore, the total amount of adhered particles in an artificial vessel was developed. Comparisons between in vitro experiments and simulations showed that the required experimental magnetic moments were greater than the theoretically estimated magnetic moments. This paper presents a method for investigating magnetic fields and for determining the magnetic moment of particles by simulation of their trajectories. The detailed function of magnetic drug targeting is of great importance in animal studies and in human therapies

Keywords

cancer; drugs; magnetic fields; magnetic moments; magnetic particles; nanoparticles; patient treatment; superparamagnetism; artificial vessel; cancer; high-gradient magnetic field; in vitro experiments; magnetic drug targeting; magnetic moment; particles trajectories; superparamagnetic nanoparticles; Cancer; Drugs; Estimation theory; In vitro; Magnetic fields; Magnetic moments; Nanoparticles; Prediction algorithms; Predictive models; Trajectory; Biomagnetics; biomedical engineering; cancer; magnetostatics; magnets;

fLanguage

English

Journal_Title

Nanotechnology, IEEE Transactions on

Publisher

ieee

ISSN

1536-125X

Type

jour

DOI

10.1109/TNANO.2007.891829

Filename

4126509