Modulation of mRNA circadian transcription cycle by microRNAs

Author

Ptitsyn, Andrey ; Ptitsyna, Natalia ; Elsebakhi, Emad ; Marincola, Francesco ; Al-Ali, Rashid ; Temanni, M.-Ramzi ; AlSaad, Rawan ; Wang, Eddie

Author_Institution

Sidra Med. & Res. Center, Doha, Qatar

fYear

2014

fDate

17-20 Feb. 2014

Firstpage

180

Lastpage

183

Abstract

MicroRNAs are important modulators of gene expression. There is anecdotal evidence that the abundance of some microRNAs varies in circadian or approximately daily rhythm. In this study, using publicly available data we attempt a systematic analysis of co-expression between microRNAs and their prospective mRNA targets. An advanced analysis of periodicity with the application of digital filters in phase continuum revealed a baseline rhythmic oscillation on over 80% of both mRNA and microRNA populations. This computational observation adds evidence to the theory that microRNAs play an active role in modulation of rhythmic expression as a general rule rather than special exemption. We also explore the immediate implications of inferred oscillatory behavior for modeling of mRNA-miRNA dynamics.

Keywords

RNA; biochemistry; circadian rhythms; digital filters; genetics; molecular biophysics; anecdotal evidence; baseline rhythmic oscillation; digital filters; gene expression; mRNA circadian transcription cycle modulation; mRNA-miRNA dynamics; microRNA populations; phase continuum; rhythmic expression; systematic analysis; Clocks; Gene expression; Mathematical model; Oscillators; RNA; Smoothing methods; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering (MECBME), 2014 Middle East Conference on

Conference_Location

Doha

Type

conf

DOI

10.1109/MECBME.2014.6783235

Filename

6783235