Title :
Scattering-Based Cytometric Detection Using Integrated Arrayed Waveguides With Microfluidics
Author :
Chen, Chun-Hao ; Tsai, Frank ; Lien, Victor ; Justis, Nicole ; Lo, Yu-Hwa
Author_Institution :
Dept. of Electr. & Comput. Eng, Univ. of California San Diego, La Jolla, CA
fDate :
3/15/2007 12:00:00 AM
Abstract :
Scattering-based on-chip excitation and detection on the arrayed-waveguide platform has been developed and implemented. Detected signals were processed with the proposed multiplication-based cross-correlation algorithm. The algorithm is capable of not only achieving signal enhancement (80 dB relative to the untreated signals) but also velocity measurement. Thus, particles flowing at different speed could also be accurately detected. Processed signals were verified by comparison to frame-by-frame video images, showing excellent correspondence. The signal processing algorithm can be easily extended to real-time on-chip detection
Keywords :
biological techniques; flow measurement; integrated optics; lab-on-a-chip; light scattering; microfluidics; microsensors; optical arrays; optical correlation; optical sensors; optical waveguides; arrayed waveguides; arrayed-waveguide platform; cross-correlation algorithm; cytometric detection; frame-by-frame video images; integrated waveguides; lab-on-a-chip flow cytometry; microfluidics; multiplication-based algorithm; on-chip detection; on-chip excitation; particle flow; real-time detection; scattering-based detection; signal detection; signal enhancement; signal processing algorithm; velocity measurement; Light scattering; Microfluidics; Optical arrays; Optical coupling; Optical refraction; Optical scattering; Optical variables control; Optical waveguides; Particle scattering; Signal processing algorithms; Biosensor; flow cytometer; integrated optics; optical waveguide; scattering;
Journal_Title :
Photonics Technology Letters, IEEE
DOI :
10.1109/LPT.2007.892906
