A biomolecular computing method based on Rho family GTPases

Author

Liu, Jian-Qin ; Shimohara, Katsunori

Author_Institution

ATR Human Inf. Sci. Labs., Kyoto, Japan

Volume

2

Issue

2

fYear

2003

fDate

6/1/2003 12:00:00 AM

Firstpage

58

Lastpage

62

Abstract

In this paper, we propose a new biomolecular computing method based on Rho family GTPases, and discuss the schemes of representation and operations of molecular computing by Rho family GTPases applied to solve large-scale 3-SAT problems. We also present the optimal condition for the regulation schemes dependent on the temperature, kinase activity, and types of cells. This work is important for potential implementation of biomolecular computers using Rho family GTPases in which an optimized controlling scheme can make the best use of the interactions of signaling pathways in a computing system made by the large-scale abundance of kinases and phosphatases in cells.

Keywords

biocomputers; cellular biophysics; molecular biophysics; proteins; 3-SAT problem solving; Rho family GTPases; biomolecular computing method; computing system; kinases; optimal condition; optimized controlling scheme; phosphatases; signaling pathways interactions; Biological materials; Biology computing; Concurrent computing; Control systems; DNA computing; Humans; Large-scale systems; Logic; Molecular computing; Nanobioscience; Algorithms; Cell Culture Techniques; Cell Physiology; Computer Simulation; Computers, Molecular; Computing Methodologies; Feasibility Studies; Models, Biological; Nanotechnology; Numerical Analysis, Computer-Assisted; Signal Transduction; rho GTP-Binding Proteins;

fLanguage

English

Journal_Title

NanoBioscience, IEEE Transactions on

Publisher

ieee

ISSN

1536-1241

Type

jour

DOI

10.1109/TNB.2003.813935

Filename

1209631