DocumentCode :
1239606
Title :
High-speed optical observations and simulation results of SonoVue microbubbles at low-pressure insonation
Author :
Chetty, Kevin ; Stride, Eleanor ; Sennoga, Charles A. ; Hajnal, Joseph V. ; Eckersley, Robert J.
Author_Institution :
Imaging Sci. Dept., Imperial Coll. London, London
Volume :
55
Issue :
6
fYear :
2008
fDate :
6/1/2008 12:00:00 AM
Firstpage :
1333
Lastpage :
1342
Abstract :
Modified Rayleigh-Plesset models are commonly used to characterize the acoustic response of microbubbles under ultrasound exposure. In most instances these models have been parameterized through acoustic measurements taken from bulk suspensions of microbubbles. The aim of this study was to parameterize the Hoff model for the commercial contrast agent SonoVue using optically observed oscillations from individual microbubbles recorded with a high-speed camera. The shell elasticity model term was tuned to fit simulation data to the measured oscillations while the shell viscosity parameter was held constant at 1 Pamiddots. The results demonstrate a limited ability of the model to predict the microbubble behavior. The shell elasticity parameter was found to vary proportionally between 10 and 80 MPa with the initial microbubble diameter, implying the viscoelastic shell terms are not a constant property of the shell material. Further analysis using a moving window optimization to probe the microbubble responses suggests that the elasticity of the shell can increase by up to 50% over the course of insonation, particularly for microbubbles oscillating nearer to their resonant frequency. Microbubble oscillations were modeled more successfully by incorporating a varying elasticity term into the model.
Keywords :
biomedical ultrasonics; bubbles; flow visualisation; high-speed optical techniques; Hoff model; Rayleigh-Plesset models; SonoVue microbubbles; blood perfusion; contrast agents; diagnostic ultrasound; high speed optical observations; insonation; shell elasticity parameter; shell viscosity parameter; therapeutic applications; Acoustic measurements; Cameras; Elasticity; High speed optical techniques; Optical recording; Predictive models; Probes; Suspensions; Ultrasonic imaging; Viscosity; Computer Simulation; Contrast Media; Microbubbles; Models, Chemical; Phospholipids; Pressure; Sonication; Sulfur Hexafluoride; Ultrasonography;
fLanguage :
English
Journal_Title :
Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on
Publisher :
ieee
ISSN :
0885-3010
Type :
jour
DOI :
10.1109/TUFFC.2008.796
Filename :
4536928
Link To Document :
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