Title :
Modeling transport through synthetic nanopores
Author :
Aksimentiev, Aleksei ; Brunner, Robert K. ; Cruz-chÙ, Eduardo ; Comer, Jeffrey ; Schulten, Klaus
Author_Institution :
Dept. of Phys., Univ. of Illinois, Urbana, IL
fDate :
3/1/2009 12:00:00 AM
Abstract :
Synthetic nanopores have arisen as a convenient means of characterizing single molecules, with DNA being one of the most popular subjects. By applying an electric field, ions and charged biomolecules like DNA can be compelled to interact with, or translocate through, nanopores in thin membranes. The use of the nanopore method for characterizing nucleic acids gained initial momentum in 1996 with a landmark paper by Kasianowicz et al.
Keywords :
DNA; biomembranes; electric fields; flow simulation; flow through porous media; molecular biophysics; nanofluidics; nanoporous materials; DNA; charged biomolecules; electric field; modeling transport; nucleic acids; synthetic nanopores; thin membranes; Biological materials; Biomembranes; Computational modeling; DNA; Geometry; Molecular biophysics; Nanoporous materials; Proteins; Protocols; Silicon;
Journal_Title :
Nanotechnology Magazine, IEEE
DOI :
10.1109/MNANO.2008.931112
