Inhibitory Effects of Moderate Static Magnetic Field on Leukemia

Author

Yang, Pengfei ; Hu, Lifang ; Wang, Zhe ; Ding, Chong ; Zhang, Wei ; Qian, Airong ; Shang, Peng

Author_Institution

Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Shaanxi

Volume

45

Issue

5

fYear

2009

fDate

5/1/2009 12:00:00 AM

Firstpage

2136

Lastpage

2139

Abstract

The purpose of this study is to investigate the effects of moderate static magnetic field (SMF, 0.2-0.4 T) on experimental murine leukemia and its possible mechanism. As in vivo and in vitro models, normal mice, mice bearing L1210 tumor and L1210 cell line were exposed to moderate SMF, respectively. The results showed that the average lifetime of mice bearing L1210 was prolonged to 12 days by SMF, but just 6 days in the unexposure group. After being exposed to SMF for 10 days, the spleen and thymus index of normal mice increased. The L1210 cell proliferation was suppressed by SMF within the first 3 days but enhanced in the following 2 days. These results suggested that the regulating effects of SMF on immune functions may have potential contribution to tumor therapy.

Keywords

biological effects of radiation; biological organs; blood; cancer; cellular biophysics; cellular effects of radiation; radiation therapy; tumours; L1210 cell line; L1210 tumor; average mice lifetime; inhibitory effects; moderate static magnetic field; murine leukemia; spleen; static magnetic field; thymus index; tumor therapy; Immune function; leukemia; proliferation; static magnetic field; tumor;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2009.2012703

Filename

4816011