Title :
Poisson-Nernst-Planck theory approach to the calculation of current through biological ion channels
Author :
Coalson, Rob D. ; Kurnikova, Maria G.
Author_Institution :
Dept. of Chem., Univ. of Pittsburgh, PA, USA
fDate :
3/1/2005 12:00:00 AM
Abstract :
The Poisson-Nernst-Planck (PNP) theory of electro-diffusion is reviewed. Techniques for numerical solution of the three-dimensional PNP equations are summarized, and several illustrative applications to ion transport through protein channels are presented. Strengths and weaknesses of the theory are discussed, as well as attempts to improve it via increasingly realistic evaluation of the force acting on each ion due to the protein/membrane environment.
Keywords :
biodiffusion; bioelectric phenomena; biomembrane transport; molecular biophysics; proteins; reviews; Poisson-Nernst-Planck theory; biological ion channels; biomembrane; electro-diffusion; ion transport; protein channels; review; Biomembranes; Cells (biology); Chemistry; Dielectric liquids; Electric potential; Lipidomics; Modeling; Poisson equations; Protein engineering; Voltage; Biological system modeling; biomembranes; dielectric liquids; finite difference methods; potential of mean force; protein fluctuations; Animals; Cell Membrane; Cell Membrane Permeability; Computer Simulation; Electric Conductivity; Gramicidin; Humans; Ion Channel Gating; Ion Channels; Lipid Bilayers; Membrane Potentials; Models, Biological; Models, Chemical; Porosity; Protein Conformation; Structure-Activity Relationship;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2004.842495
