Title :
Microchip technology in ion-channel research
Author :
Sigworth, Fred J. ; Klemic, Kathryn G.
Author_Institution :
Dept. of Cellular & Molecular Physiol., Yale Univ., New Haven, CT, USA
fDate :
3/1/2005 12:00:00 AM
Abstract :
The electrical activity of living cells can be monitored in various ways, but for the study of ion channels and the drugs that affect them, the patch-clamp techniques are the most sensitive. Recent developments in microfabricated patch-clamp electrodes are reviewed, and technical challenges for the future are discussed.
Keywords :
bioelectric phenomena; biological techniques; biomembrane transport; micromechanical devices; reviews; drugs; electrical activity; ion channel; living cells; microchip technology; microfabricated patch-clamp electrodes; patch-clamp techniques; review; Biomembranes; Drugs; Electrodes; Heart; Monitoring; Muscles; Pharmaceutical technology; Proteins; Testing; Voltage; Amplifier noise; bioelectric phenomena; biomembranes; micromachining; Action Potentials; Cell Culture Techniques; Equipment Design; Ion Channel Gating; Ion Channels; Membrane Potentials; Microchip Analytical Procedures; Nanotechnology; Patch-Clamp Techniques; Research;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2004.842471
