Title :
A Controlled-Release Drug Delivery System on a Chip Using Electrolysis
Author :
Huang, Pen-Li ; Kuo, Po-Hung ; Huang, Yu-Jie ; Liao, Hsin-Hung ; Yang, Yao-Joe Joseph ; Wang, Tao ; Wang, Yao-Hung ; Lu, Shey-Shi
Author_Institution :
Dept. of Electr. Eng., Nat. Taiwan Univ., Taipei, Taiwan
fDate :
3/1/2012 12:00:00 AM
Abstract :
A system-on-a-chip (SOC) with integrated drug reservoirs for drug delivery is proposed. Electrolysis is used to generate microbubbles, which are employed as a force to open the reservoirs and release the drug. Wireless components, including an on/off keying receiver, microcontrol unit, regulator, clock divider, and power-on reset, are integrated for remote drug activation. The proposed microchip is fabricated by Taiwan Semiconductor Manufacturing Company 0.35-μm CMOS technology followed by post-IC processing. The total size is 2.48 mm2, and the power consumption is 7.57 mW. The in vitro experiment has proven the feasibility of the proposed drug delivery SOC.
Keywords :
CMOS integrated circuits; biomedical electronics; drug delivery systems; electrolysis; system-on-chip; CMOS technology; Taiwan Semiconductor Manufacturing Company; clock divider; controlled-release drug delivery SOC; controlled-release drug delivery system-on-a-chip; electrolysis; in vitro experiment; integrated drug reservoir; microbubble generation; microchip; microcontrol unit; on-off keying receiver; post-IC processing; power 7.57 mW; power consumption; power-on reset; regulator; remote drug activation integration; size 0.35 mum; Clocks; Drug delivery; Drugs; Electrodes; Receivers; Reservoirs; System-on-a-chip; Biomedical; CMOS integrated circuit (IC); drug delivery; system-on-a-chip;
Journal_Title :
Industrial Electronics, IEEE Transactions on
DOI :
10.1109/TIE.2011.2160135
