Title :
In vivo infrared tomographic imaging of laser-heated blood vessels
Author :
Telenkov, Sergey A. ; Tanenbaum, B.S. ; Goodman, Dennis M. ; Nelson, Jeffrey S. ; Milner, Thomas E.
Author_Institution :
Biomed. Eng. Program, Texas Univ., Austin, TX, USA
Abstract :
We demonstrate a method for infrared tomographic imaging of the initial three-dimensional (3-D) temperature increase of in vivo blood vessels following pulsed laser exposure. Using a time-sequence of infrared images recorded by a fast focal plane array camera as input data, a reconstruction algorithm is used to compute the initial 3-D temperature increases in the chick chorioallantoic membrane and port wine stain in human skin. The noncontact tomographic imaging method is relevant to various laser therapies that rely on a photothermal mechanism for selective modification of tissue and may find diagnostic application to determine optimal laser dosimetry, position, and size of targeted subsurface chromophores
Keywords :
biothermics; blood vessels; dosimetry; image reconstruction; infrared imaging; laser applications in medicine; medical image processing; optical tomography; photothermal effects; radiation therapy; skin; chick chorioallantoic membrane; fast focal plane array camera; human skin; in vivo blood vessels; in vivo infrared tomographic imaging; infrared images; initial three-dimensional temperature increase; input data; laser therapies; laser-heated blood vessels; noncontact tomographic imaging method; optimal laser dosimetry; photothermal mechanism; port wine stain; position; pulsed laser exposure; reconstruction algorithm; size; targeted subsurface chromophores; time-sequence; Biomedical imaging; Blood vessels; Cameras; In vivo; Infrared imaging; Optical imaging; Optical pulses; Reconstruction algorithms; Temperature; Tomography;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/2944.796346
