Title :
In Silico Studies of Magnetic Microparticle Aggregations in Fluid Environments for MRI-Guided Drug Delivery
Author :
Vartholomeos, P. ; Mavroidis, Constantinos
Author_Institution :
Cardiac Surg. Bioeng. Lab., Children´s Hosp. Boston, Boston, MA, USA
Abstract :
A computational platform has been developed to perform simulation, visualization, and postprocessing analysis of the aggregation process of magnetic particles within a fluid environment such as small arteries and arterioles or fluid-filled cavities of the human body. The mathematical models needed to describe the physics of the system are presented in detail and also computational algorithms needed for efficient computation of these models are described. A number of simulation results demonstrate the simulation capabilities of the platform and preliminary experimental results validate simulation predictions. The platform can be used to design optimal strategies for magnetic steering and magnetic targeting of drug-loaded magnetic microparticles.
Keywords :
aggregation; biomedical MRI; blood vessels; digital simulation; drug delivery systems; haemorheology; magnetic particles; mathematical analysis; medical image processing; nanomedicine; MRI-guided drug delivery; arteries; arterioles; computational algorithms; drug-loaded magnetic microparticles; fluid environments; fluid-filled cavities; human body; in silico study; magnetic microparticle aggregation process; magnetic steering; magnetic targeting; mathematical models; postprocessing analysis; visualization analysis; Computational modeling; Fluids; Force; Magnetic forces; Magnetic particles; Magnetic resonance imaging; Mathematical model; Aggregation; MRI guided; control; magnetic microparticle; robotics; Blood Vessels; Computer Simulation; Drug Delivery Systems; Electromagnetic Fields; Hemorheology; Humans; Magnetic Resonance Imaging; Magnetite Nanoparticles; Models, Biological;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2012.2213340
