Data-based core genes screening for Hepatocellular Carcinoma

Author

Jinyu Hu ; Zhiwei Gao

Author_Institution

Dept. of Biostat. & Comput. Biol., Univ. of Rochester, Rochester, NY, USA

fYear

2014

fDate

9-11 June 2014

Firstpage

1102

Lastpage

1107

Abstract

In terms of the concepts of gene force and gene community network, a novel multi-layer filter is proposed to screen the core genes. Applying the present algorithm to liver cancer microarray data with 3964 genes, the three core genes, composed of iron-related gene HAMP, metal-related metallothionein genes, and tumor proliferation-related GPC3 gene are screened. Based on these core genes, the formation and development mechanism of the HCC and the relationship between the HCC and trace metals, such as copper, iron and zinc, are analyzed and revealed.

Keywords

cancer; cellular biophysics; copper compounds; filtering theory; genetic algorithms; genetics; iron compounds; liver; medical diagnostic computing; molecular biophysics; proteins; zinc compounds; HCC development mechanism; HCC formation; data-based core genes screening; gene community network; gene force; hepatocellular carcinoma; iron-related gene HAMP; liver cancer microarray data algorithm; metal-related metallothionein genes; multilayer filter; trace metals; tumor proliferation-related GPC3 gene; Cancer; Copper; Correlation; Filtering algorithms; Iron; Liver; Zinc; core genes; data-based analysis; gene community network; hepatocellular carcinoma;

fLanguage

English

Publisher

ieee

Conference_Titel

Industrial Electronics and Applications (ICIEA), 2014 IEEE 9th Conference on

Conference_Location

Hangzhou

Print_ISBN

978-1-4799-4316-6

Type

conf

DOI

10.1109/ICIEA.2014.6931330

Filename

6931330