Title :
Integrating microfabricated fluidic systems and NMR spectroscopy
Author :
Trumbull, J.D. ; Glasgow, I.K. ; Beebe, D.J. ; Magin, R.L.
Author_Institution :
Beckman Inst. for Adv. Sci. & Technol., Illinois Univ., Urbana, IL, USA
Abstract :
The philosophy of miniature total analysis systems (μ-TAS) hinges on the multiple chemical processing steps and the means of analyzing their results on the same miniaturized system. We have constructed chip-based capillary electrophoresis (CE) devices equipped with an integrated planar radio-frequency detector coil used for nuclear magnetic resonance spectroscopy (NMR). Separations were accomplished in the devices, but satisfactory NMR spectra could only be obtained from samples of high concentration. The relative sensitivity is explained and the scaling law dichotomy of CE and NMR explored.
Keywords :
NMR spectroscopy; coils; electrochemical sensors; electrophoresis; microfluidics; microsensors; separation; spectrochemical analysis; NMR spectroscopy; chip-based capillary electrophoresis devices; fraction collection; high concentration samples; integrated planar RF detector coil; microcoil; microfabricated fluidic systems; miniature total analysis systems; miniaturized system; multiple chemical processing steps; relative sensitivity; scaling law dichotomy; Chemical analysis; Chemical processes; Electrokinetics; Fasteners; Fluidic microsystems; Magnetic analysis; Microfluidics; Nuclear magnetic resonance; Radio frequency; Spectroscopy; Electrophoresis, Capillary; Equipment Design; Magnetic Resonance Spectroscopy; Sensitivity and Specificity;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
