Title :
Reproducibility of MEG auditory evoked field source localizations in normal human subjects using a seven-channel gradiometer
Author :
Teale, Peter ; Goldstein, Leigh ; Reite, Martin ; Sheeder, Jeanelle ; Richardson, Douglas ; Edrich, Jochen ; Zimmerman, James E.
Author_Institution :
Dept. of Psychiatry, Univ. of Colorado Health Sci. Centre, Denver, CO, USA
Abstract :
Magnetoencephalographic (MEG) auditory evoked fields (EF) were recorded from 12 normal adult subjects over both hemispheres on two separate occasions at least one week apart using a seven-channel second-order gradiometer. Stimuli were computer-generated at 25-msec duration, 1 kHz tone pips. Responses to 100 stimuli were averaged, and source estimates with confidence intervals were computed, for the 100-msec latency auditory EF component, termed M100. Root-mean-squared (rms) differences in x, y, and z locations were approximately 0.7 cm on the two occasions; strength and orientation differences were 18 nA-m and 11°, respectively. This spatial accuracy using a seven-channel instrument, compares favorably with other currently available technologies for localization of brain function.
Keywords :
hearing; magnetoencephalography; measurement errors; 1 kHz; 1 wk; 100 ms; 25 ms; MEG auditory evoked field source localizations reproducibility; brain function localization; cerebral hemispheres; normal adult subjects; normal human subjects; root-mean-squared differences; seven-channel gradiometer; spatial accuracy; tone pips; Delay; Humans; Instruments; Laboratories; Magnetic field measurement; Magnetic recording; Magnetic separation; Psychology; Reproducibility of results; Sampling methods; Adult; Analysis of Variance; Confidence Intervals; Evoked Potentials, Auditory; Female; Humans; Magnetoencephalography; Male; Reference Values; Reproducibility of Results;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
