DocumentCode :
1294397
Title :
A Stochastic Multi-Scale Model of Electrical Function in Normal and Depleted ICC Networks
Author :
Gao, Jerry ; Du, Peng ; Archer, Rosalind ; OrGrady, G. ; Gibbons, Simon J. ; Farrugia, Gianrico ; Cheng, Leo K. ; Pullan, Andrew J.
Author_Institution :
Auckland Bioeng. Inst., Univ. of Auckland, Auckland, New Zealand
Volume :
58
Issue :
12
fYear :
2011
Firstpage :
3451
Lastpage :
3455
Abstract :
Multi-scale modeling has become a productive strategy for quantifying interstitial cells of Cajal (ICC) network structure-function relationships, but the lack of large-scale ICC network imaging data currently limits modeling progress. The single normal equation simulation (SNESIM) algorithm was utilized to generate realistic virtual images of small real wild-type (WT) and 5-HT2B-receptor knockout (Htr2b)-/-) mice ICC networks. Two metrics were developed to validate the performance of the algorithm: 1) network density, which is the proportion of ICC in the tissue; and 2) connectivity, which reflects the degree of connectivity of the ICC network. Following validation, the SNESIM algorithm was modified to allow variation in the degree of ICC network depletion. ICC networks from a range of depletion severities were generated, and the electrical activity over these networks was simulated. The virtual ICC networks generated by the original SNESIM algorithm were similar to that of their real counterparts. The electrical activity simulations showed that the maximum current density magnitude increased as the network density increased. In conclusion, the SNESIM algorithm is an effective tool for generating realistic virtual ICC networks. The modified SNESIM algorithm can be used with simulation techniques to quantify the physiological consequences of ICC network depletion at various physical scales.
Keywords :
bioelectric phenomena; biomedical imaging; cellular biophysics; stochastic processes; 5-HT2B-receptor knockout mice ICC network; ICC network depletion; SNESIM algorithm; current density; depleted ICC network; electrical activity; electrical function; interstitial cells of Cajal network; normal ICC network; physiological consequences; single normal equation simulation algorithm; stochastic multiscale model; Current density; Data models; Interpolation; Mathematical model; Mice; Training; Gastroenterology; image generation; interstitial cells of Cajal (ICC); single normal equation simulation (SNESIM); Algorithms; Animals; Computer Simulation; Diagnostic Techniques, Digestive System; Electrodiagnosis; Interstitial Cells of Cajal; Mice; Mice, Knockout; Models, Biological; Receptor, Serotonin, 5-HT2B; Reproducibility of Results;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2011.2164248
Filename :
5979206
Link To Document :
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