Well-defined thermo-responsive polymeric nanocapsules by a one-pot method via surface-initiated atom transfer radical copolymerisation

Author

Du, Peijun ; Mu, B. ; Shen, Rongjun ; Liu, Peng

Author_Institution

State Key Lab. of Appl. Org. Chem., Lanzhou Univ., Lanzhou, China

Volume

4

Issue

3

fYear

2010

fDate

9/1/2010 12:00:00 AM

Firstpage

72

Lastpage

76

Abstract

The well-defined thermo-responsive polymeric nanocapsules were prepared by the one-pot approach via the surface-initiated atom transfer radical copolymerisation of N-isopropyl acrylamide (NIPAM) and N, N-methylenebisacylamide (MBA) from the silica nanoparticle templates after the silica templates were removed by hydrofluoric acid (HF). The diameter of the polymeric nanocapsules is in the range of 20-40 nm, characterised by transmission electron microscopy (TEM). The temperature-induced dimensional change of the thermo-responsive polymeric nanocapsules was investigated by dynamic light scattering (DLS) in aqueous solutions. The intelligent thermo-responsive polymeric nanocapsules are expected to be used for the controlled release of sensitive molecules, such as enzymes, proteins or DNA, by changing the environmental temperature.

Keywords

biomedical materials; intelligent materials; light scattering; nanobiotechnology; nanofabrication; nanostructured materials; polymerisation; polymers; transmission electron microscopy; N, N-methylenebisacylamide; N-isopropyl acrylamide; dynamic light scattering; intelligent thermo-responsive polymeric nanocapsules; one-pot method; size 20 nm to 40 nm; surface-initiated atom transfer radical copolymerisation; transmission electron microscopy;

fLanguage

English

Journal_Title

Nanobiotechnology, IET

Publisher

iet

ISSN

1751-8741

Type

jour

DOI

10.1049/iet-nbt.2009.0017

Filename

5551076