Title :
Independent Sets of DNA Oligonucleotides for Nanotechnology Applications
Author :
Yu, Weixia ; Lee, Ju Seok ; Johnson, Cole ; Kim, Jin-woo ; Deaton, Russell
Author_Institution :
Dept. of Comput. Sci. & Comput. Eng., Univ. of Arkansas, Fayetteville, AR, USA
fDate :
3/1/2010 12:00:00 AM
Abstract :
Independent sets of DNA oligonucleotides, which only bind with their Watson-Crick complements, have potential use in self-assembly of nanostructures, since they minimize errors and inefficiency from unwanted binding. A software tool implemented a thermodynamic model for DNA duplex formation and was used to generate large independent sets of DNA oligonucleotides. The principle of the approach was experimentally verified on a sample set of oligonucleotides.
Keywords :
DNA; molecular biophysics; molecular configurations; nanobiotechnology; nanostructured materials; self-assembly; thermodynamics; DNA duplex formation; DNA oligonucleotides; Watson-Crick complements; nanostructures; nanotechnology applications; self-assembly; software tool; thermodynamic model; DNA; dynamic programming; message passing; nanotechnology; Algorithms; Computational Biology; Computer Simulation; DNA; Electrophoresis, Polyacrylamide Gel; Models, Genetic; Nanotechnology; Nucleic Acid Hybridization; Oligonucleotides; Reproducibility of Results; Software; Thermodynamics;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2009.2035446
