• DocumentCode
    1311423
  • Title

    On the Modeling of New Tunnel Junction Magnetoresistive Biosensors

  • Author

    De Almeida, Teresa Mendes ; Piedade, Moisé S S ; Sousa, Leonel Augusto ; Germano, José ; Lopes, Paulo A C ; Cardoso, Filipe Arroyo ; Freitas, Paulo Peixeiro

  • Author_Institution
    Inst. de Eng. de Sist. e Comput.-R&D (INESC-ID), Lisbon, Portugal
  • Volume
    59
  • Issue
    1
  • fYear
    2010
  • Firstpage
    92
  • Lastpage
    100
  • Abstract
    A fully integrated biochip based on a 16 ?? 16 scalable matrix structure of aluminum oxide magnetic tunnel junctions (MTJs) and thin-film diodes (TFDs of hydrogenated amorphous silicon) was fabricated and included as the biosensor of a portable handheld microsystem developed for biomolecular recognition detection using magnetic labels [deoxyribonucleic acid (DNA) hybridization, antibody antigen interaction, etc.]. The system uses magnetic field arraying of magnetically tagged biomolecules and can potentially be used to detect single or few biomolecules. Each biosensor matrix node is the series between a TFD (p-i-n or Schottky-barrier type) and an MTJ. In this paper, this matrix basic cell biosensor element is completely characterized and modeled. Experimental measured data are provided and compared with the proposed theoretical models results. It is shown that the diode may be used both as the matrix switching device and as an in-site temperature sensor and that the MTJ may act as the magnetoresistive sensor for detecting the fringe field of immobilized magnetic markers. Therefore, the fabricated fully integrated biochip included in the developed handheld microsystem may be used for biomolecular recognition.
  • Keywords
    DNA; biosensors; magnetoresistive devices; molecular biophysics; portable instruments; DNA hybridization; antibody antigen interaction; biomolecular recognition; deoxyribonucleic acid; magnetic field arraying; magnetoresistive biosensors; portable handheld microsystem; thin film diodes; tunnel junction; Biomedical transducers; Schottky diodes; magnetoresistive devices; p-i-n diodes; system modeling;
  • fLanguage
    English
  • Journal_Title
    Instrumentation and Measurement, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    0018-9456
  • Type

    jour

  • DOI
    10.1109/TIM.2009.2022100
  • Filename
    5325788