Title :
LED-Based Optical Device for Chronic In Vivo Cerebral Blood Volume Measurement
Author :
Cox, Marshall P. ; Ma, Hongtao ; Bahlke, Matthias E. ; Beck, Jonathan H. ; Schwartz, Theodore H. ; Kymissis, Ioannis
Author_Institution :
Dept. of Electr. Eng., Columbia Univ., New York, NY, USA
Abstract :
We demonstrate a reflectivity-based cerebral blood volume sensor comprised of surface-mount light-emitting diodes on a flexible substrate with integrated photodetectors in a form factor suitable for direct brain contact and chronic implantation. This reflectivity monitor is able to measure blood flow through the change of the surface reflectivity and, through this mechanism, detect the cerebral-blood-volume changes associated with epileptic seizures with a signal-to-noise (SNR) response of 42 dB. The device is tested in an in vivo model confirming its compatibility and sensitivity. The data taken demonstrate that placing the sensor into direct brain contact improves the SNR by more than four orders of magnitude over current noncontact technologies.
Keywords :
blood flow measurement; brain; light emitting diodes; neurophysiology; photodetectors; volume measurement; LED based optical device; blood flow measurement; cerebral blood-volume changes; chronic implantation; chronic in vivo cerebral blood volume measurement; direct brain contact; epileptic seizures; integrated photodetectors; light emitting diodes; reflectivity based cerebral blood volume sensor; surface mount LED; surface reflectivity change; Blood flow; Epilepsy; Fluid flow measurement; In vivo; Light emitting diodes; Monitoring; Optical devices; Photodetectors; Reflectivity; Testing; Biomedical optical imaging; surface mounting; time–frequency analysis;
Journal_Title :
Electron Devices, IEEE Transactions on
DOI :
10.1109/TED.2009.2033652
