DocumentCode :
1320157
Title :
Effect of Extremely Low-Frequency (ELF) Magnetic Fields on Anticancer Drugs Potency
Author :
Kakikawa, Makiko ; Yamada, Sotoshi
Author_Institution :
Inst. of Nature & Environ. Technol., Kanazawa Univ., Ishikawa, Japan
Volume :
48
Issue :
11
fYear :
2012
Firstpage :
2869
Lastpage :
2872
Abstract :
There are some reports about combined effects of electromagnetic fields with known carcinogens, toxic physical or chemical agents. In previous study, we observed that magnetic fields (60 Hz, 50 mT) enhance cytotoxicity of mitomycin C on E.coli bacterium. However, it has not been clear about the effective condition of magnetic fields (magnetic flux density, frequency, exposure time etc.) on the potency of chemical agents. In this study, we investigated the effective density and the action mechanisms of magnetic fields on the enhancement of drugs potency. The result suggested that the enhancing effect of mitomycin C potency by exposure to magnetic fields depended on the magnetic flux density. The potency of cisplatin, widely used in clinical cancer chemotherapy, was also enhanced by exposure to 60 Hz, 50 mT magnetic fields. The analysis of the potency of supernatant remaining drugs in the culture medium indicated that the intracellular drug potency was increased and extracellular drug potency was decreased by exposure to magnetic fields. The values of drug potency revealed a significant inverse correlation between intracellular and extracellular cells. These results suggested that magnetic fields (60 Hz, 50 mT) change the permeability of cell membrane and influence the drug intake.
Keywords :
biomembranes; cancer; cellular biophysics; drugs; electromagnetic fields; magnetic field effects; magnetic flux; microorganisms; organic compounds; patient treatment; toxicology; E.coli bacterium; anticancer drugs potency; carcinogens; cell membrane; cisplatin potency; clinical cancer chemotherapy; culture medium; cytotoxicity; drug intake; electromagnetic fields effects; extracellular cells; extracellular drug potency; frequency 60 Hz; intracellular cells; intracellular drug potency; inverse correlation; low-frequency magnetic field effect; magnetic field exposure; magnetic flux density; mitomycin C; permeability; supernatant potency; toxic chemical agents; toxic physical agents; Cells (biology); Drugs; Geophysical measurement techniques; Ground penetrating radar; Magnetic levitation; Magnetic resonance; Magnetosphere; Anticancer drug; Extremely Low-Frequency (ELF) magnetic fields; enhancing effect; membrane permeability;
fLanguage :
English
Journal_Title :
Magnetics, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9464
Type :
jour
DOI :
10.1109/TMAG.2012.2200881
Filename :
6332585
Link To Document :
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