Title :
The Application of Magnetic Resonance Perfusion Imaging in the Estimation of Brain Function Using SVD Method
Author :
Li, Ying ; Ma, Dongmin ; He, Renjie ; Rao, Liyun ; Guo, Lei ; Chen, Jie ; Xu, Guizhi
Author_Institution :
Province-Minist. Joint Key Lab. of Electromagn. Field & Electr. Apparatus Reliability, Hebei Univ. of Technol., Tianjin, China
Abstract :
MR perfusion imaging can be used to estimate parameters indicating the metabolic process, including cerebral blood flow (CBF). Specifically singular value decomposition (SVD) method is applied in this paper to obtain CBF with a predefined conventional arterial input function (AIF), and the effects of threshold and tracer delay are investigated. While the simulation results show that SVD method can estimate CBF with good accuracy by using different thresholds for different flow values, the method is found to be sensitive to tracer delay. A delay correction scheme is advocated, where CBF is determined by SVD after time-shifting of the tracer concentration curve. With the correction the simulation results are considerably improved in the flow estimation.
Keywords :
biomedical MRI; blood; blood vessels; brain; haemorheology; medical signal processing; signal denoising; singular value decomposition; ίow estimation; SVD method; brain function estimation; cerebral blood flow; conventional arterial input function; delay correction scheme; magnetic resonance perfusion imaging application; metabolic process; signal denoising; singular value decomposition; time shifting; tracer concentration curve; tracer delay threshold effects; Accuracy; Blood; Delay; Estimation; Magnetic resonance imaging; Matrix decomposition; CBF estimation; MR perfusion imaging; SVD method; simulation experiments; tracer delay correction;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2012.2196993
