ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries

Author

Filipovic, Nenad ; Rosic, Mirko ; Tanaskovic, Irena ; Milosevic, Zarko ; Nikolic, Dalibor ; Zdravkovic, Nebojsa ; Peulic, Aleksandar ; Kojic, Milos R. ; Fotiadis, Dimitris I. ; Parodi, Oberdan

Author_Institution

Fac. of Mech. Eng., Univ. of Kragujevac, Kragujevac, Serbia

Volume

16

Issue

2

fYear

2012

fDate

3/1/2012 12:00:00 AM

Firstpage

272

Lastpage

278

Abstract

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.

Keywords

Navier-Stokes equations; biotransport; blood vessels; diseases; flow simulation; haemodynamics; proteins; reaction-diffusion systems; 3-D Navier-Stokes equations; ARTreat project; Kedem-Katchalsky equations; atherosclerosis; blood flow; blood vessel; disease; endothelium; fibrous elements; lipids; low-density lipoprotein transport; plaque development; plaque formation; rabbit animal model; reaction-diffusion partial differential equations; straight artery model; three-dimensional numerical simulation; vasculitis; Arteries; Blood; Equations; Image segmentation; Mathematical model; Media; Atherosclerosis; low-density lipoprotein (LDL); plaque; wall shear stress; Algorithms; Animals; Blood Flow Velocity; Blood Pressure; Blood Viscosity; Computer Simulation; Imaging, Three-Dimensional; Lipoproteins, LDL; Models, Cardiovascular; Plaque, Atherosclerotic; Rabbits; Stress, Mechanical;

fLanguage

English

Journal_Title

Information Technology in Biomedicine, IEEE Transactions on

Publisher

ieee

ISSN

1089-7771

Type

jour

DOI

10.1109/TITB.2011.2168418

Filename

6021373