Title :
Magnetic PLGA Nanospheres: A Dual Therapy for Cancer
Author :
Kini, S. ; Bahadur, D. ; Panda, D.
Author_Institution :
Centre for Res. in Nanotechnol. & Sci., Indian Inst. of Technol. Bombay, Mumbai, India
Abstract :
We report a strategy for developing a poly (DL-lactide-co-glycolide) (PLGA)-based controlled polymeric drug delivery system consisting of an anticancer agent curcumin and magnetic nanoparticles (MNPs). Superparamagnetic nanoparticles of size 9 nm were used to produce heat by applying an ac magnetic field of 11.7 kA/m. We characterized the properties of magnetic PLGA nanospheres encapsulated with curcumin as a drug delivery vehicle and also as a hyperthermic agent to induce cell death in HeLa cancer cells through magnetocalorific effect. The specific absorption rate for unencapsulated MNPs and encapsulated MNPs were found to be 108 and 59 W/g, respectively. Cell death due to magnetic hyperthermia was evaluated to be 90% higher with respect to control.
Keywords :
biomedical materials; cancer; cellular biophysics; drug delivery systems; hyperthermia; magnetic particles; magnetocaloric effects; nanomagnetics; nanomedicine; nanoparticles; polymers; superparamagnetism; HeLa cancer cells; ac magnetic field; anticancer agent curcumin; cell death; drug delivery vehicle; dual therapy; hyperthermic agent; magnetic PLGA nanospheres; magnetic hyperthermia; magnetocalorific effect; poly(DL-lactide-co-glycolide); polymeric drug delivery system; size 9 nm; superparamagnetic nanoparticles; Cancer; Drug delivery; Encapsulation; Hyperthermia; Magnetic resonance imaging; Nanoparticles; Polymers; Drug delivery systems; hyperthermia; magnetic fields; magnetic material;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2011.2158403
