Microwave thermochemotherapy in the treatment of the bladder carcinoma-electromagnetic and dielectric studies-clinical protocol

Author

Dietsch, Alain ; Camart, Jean-Christophe ; Sozanski, Jean-Pierre ; Prevost, Bernard ; Mauroy, Brigitte ; Chivé, Maurice

Author_Institution

I.E.M.N., Univ. des Sci. et Technol., Poincare, France

Volume

47

Issue

5

fYear

2000

fDate

5/1/2000 12:00:00 AM

Firstpage

633

Lastpage

641

Abstract

Microwave thermotherapy is currently used in clinical routines for benign prostatic hyperplasia treatments. The temperature increase is obtained using an endocavitary microwave applicator placed in the prostatic urethra. This urethral applicator after a technical modification can be placed inside the bladder in order to potentiate the effects of the treatment by chemotherapy of vesical carcinoma. This paper deals with electromagnetic studies of this new endocavitary applicator. First of all, the experimental determination of the dielectric permittivities for the propagation domain characterization is achieved in order to be used in the electromagnetic model. Compared to experimental results, these simulations obtained by the finite-difference time-domain formalism allow us to determine the electromagnetic performance of this applicator. Finally, the in vivo study realized on anesthetized dogs to determine the therapeutic protocol associating chemotherapy and thermotherapy in the treatment of the bladder cancer is presented.

Keywords

bioelectric phenomena; biological effects of microwaves; biological organs; cancer; finite difference time-domain analysis; hyperthermia; microwave heating; patient treatment; permittivity; radiation therapy; anesthetized dogs; benign prostatic hyperplasia treatments; bladder; bladder carcinoma treatment; chemotherapy; clinical protocol; dielectric permittivities; dielectric studies; electromagnetic model; electromagnetic studies; endocavitary microwave applicator; finite-difference time-domain formalism; microwave thermochemotherapy; propagation domain characterization; prostatic urethra; technical modification; temperature increase; therapeutic protocol; thermotherapy; urethral applicator; vesical carcinoma; Applicators; Bladder; Dielectrics; Electromagnetic heating; Electromagnetic propagation; Medical treatment; Microwave technology; Permittivity; Protocols; Temperature; Animals; Antibiotics, Antineoplastic; Combined Modality Therapy; Disease Models, Animal; Dogs; Electromagnetic Fields; Finite Element Analysis; Hyperthermia, Induced; Microwaves; Mitomycin; Urinary Bladder Neoplasms;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.841335

Filename

841335