Title :
Single-Ion Channel Recordings on Quartz Substrates
Author :
Stava, Eric ; Yu, Minrui ; Shin, Hyun Cheol ; Blick, Robert H.
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Wisconsin-Madison, Madison, WI, USA
Abstract :
We show that a single-crystal quartz substrate provides a working platform for ion channel research. Single-crystal quartz is piezoelectric, so it can be nanomechanically actuated to perform precise membrane deformations. This, along with its superior noise properties, makes single-crystal quartz ideal for analyzing mechanosensitive ion channels.
Keywords :
bioelectric phenomena; biomembrane transport; nanobiotechnology; nanomechanics; piezoelectric materials; quartz; mechanosensitive ion channel; membrane deformations; nanomechanical actuation; piezoelectric materials; single-crystal quartz substrate; single-ion channel recordings; Apertures; Biomembranes; Environmental factors; Lipidomics; Piezoelectric materials; Substrates; Biomembranes; ion channels; piezoelectric; planar patch clamping; quartz; Biophysical Phenomena; Biophysics; Ion Channels; Lipid Bilayers; Quartz;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2010.2076830
