Cell deformation and increase of cytotoxicity of anticancer drugs due to low-intensity transient electromagnetic pulses

Author

Liu, Changjun ; Wang, Baoyi ; Wang, Zishu ; Zhang, Hong

Author_Institution

Dept. of Radio Electron., Sichuan Univ., Chengdu, China

Volume

28

Issue

1

fYear

2000

fDate

2/1/2000 12:00:00 AM

Firstpage

150

Lastpage

154

Abstract

In this paper, cell deformation induced by low-intensity electromagnetic pulses (EMPs) is presented. A broad-band transverse electromagnetic wave cell (BTEM cell) was used in the experimental system to simulate the free space transmission condition. The biological samples were exposed to the EMP field in the BTEM cell. After the chick´s erythrocytes were exposed to EMP field, pores on their membranes were observed by a scanning electron microscope. Cell fusion was also found between the chick´s erythrocytes as well as between the rabbit´s. In other experiments, it is found that the EMP field can increase the cytotoxicity of some anticancer drugs. The results suggest that the membrane deformation is a secondary effect of electromagnetic fields

Keywords

bioelectric phenomena; biological effects of fields; biomagnetism; blood; cancer; cellular effects of radiation; anticancer drugs; biological samples; broad-band transverse electromagnetic wave cell; cell deformation; cell fusion; chick erythrocytes; cytotoxicity; low-intensity transient electromagnetic pulses; membrane deformation; rabbit erythrocytes; scanning electron microscope; Biological system modeling; Biomembranes; Cells (biology); Drugs; EMP radiation effects; Electromagnetic fields; Electromagnetic scattering; Electromagnetic transients; Frequency; Scanning electron microscopy;

fLanguage

English

Journal_Title

Plasma Science, IEEE Transactions on

Publisher

ieee

ISSN

0093-3813

Type

jour

DOI

10.1109/27.842889

Filename

842889