• DocumentCode
    1337317
  • Title

    Toward robust integrated circuits: The embryonics approach

  • Author

    Mange, Daniel ; Sipper, Moshe ; Stauffer, André ; Tempesti, Gianluca

  • Author_Institution
    Logic Syst. Lab., Swiss Fed. Inst. of Technol., Lausanne, Switzerland
  • Volume
    88
  • Issue
    4
  • fYear
    2000
  • fDate
    4/1/2000 12:00:00 AM
  • Firstpage
    516
  • Lastpage
    543
  • Abstract
    The growth and operation of all living beings are directed by the interpretation, in each of their cells, of a chemical program, the DNA string or genome. This process is the source of inspiration for the Embryonics (embryonic electronics) project, whose final objective is the design of highly robust integrated circuits, endowed with properties usually associated with the living world: self-repair (cicatrization) and self-replication. The Embryonics architecture is based on four hierarchical levels of organization. (1) The basic primitive of our system is the molecule, a multiplexer-based element of a novel programmable circuit. (2) A finite set of molecules makes up a cell, essentially a small processor with an associated memory. (3) A finite set of cells makes up an organism, an application-specific multiprocessor system. (4) The organism can itself replicate, giving rise to a population of identical organisms. We begin by describing in detail the implementation of an artificial cell characterized by a fixed architecture, showing that multicellular arrays can realize a variety of different organisms, all capable of self-replication and self-repair. In order to allow for a wide range of applications, we then introduce a flexible architecture, realized using a new type of fine-grained field-programmable gate array whose basic element, our molecule, is essentially a programmable multiplexer. We describe the implementation of such a molecule, with built-in self-test, and illustrate its use in realizing two applications: a modulo-4 reversible counter (a unicellular organism) and a timer ( a complex multicellular organism). We describe our ongoing research efforts to meet three challenges: a scientific challenge, that of implementing the original specifications formulated by John von Neumann for the conception of a self-replicating automaton; a technical challenge, that of realizing very robust integrated circuits capable of self-repair and self-replication; and a biol- gical challenge, that of attempting to show that the microscopic architectures of artificial and natural organisms, i.e., their genomes, share common properties.
  • Keywords
    DNA; biomolecular electronics; built-in self test; cellular arrays; field programmable gate arrays; integrated circuit design; DNA string; IC design; application-specific multiprocessor system; artificial cell; associated memory; built-in self-test; cicatrization; embryonic electronics; flexible architecture; genome; hierarchical levels; identical organisms; microscopic architectures; modulo-4 reversible counter; multicellular arrays; multiplexer-based element; programmable circuit; robust integrated circuits; self-repair; self-replication; unicellular organism; Bioinformatics; Chemicals; DNA; Embryo; Field programmable gate arrays; Genomics; Multiprocessing systems; Organisms; Programmable circuits; Robustness;
  • fLanguage
    English
  • Journal_Title
    Proceedings of the IEEE
  • Publisher
    ieee
  • ISSN
    0018-9219
  • Type

    jour

  • DOI
    10.1109/5.842998
  • Filename
    842998