In vivo MRI monitoring of inflammatory alterations and cellular dynamics in the central nervous system

Author

Mori, Yuki ; Arima, Yasunobu ; Ting Chen ; Dasong Zhu ; Komai, Yutaka ; Murakami, Masaaki ; Yoshioka, Yoshichika ; Fujisawa, Tetsuya ; Kobashi, Syoji ; Hata, Yutaka

Author_Institution

WPI Immunology Frontier Res. Center, Osaka Univ., Suita, Japan

fYear

2014

fDate

3-7 Aug. 2014

Firstpage

355

Lastpage

360

Abstract

This paper demonstrates the possibility of in vivo imaging for neuroimmunological assessments using ultra high-field magnetic resonance imaging (UHF-MRI). UHF-MRI provides a highly sensitive MR microimaging technique could be used to identify previously invisible pathologies and cellular dynamics in the central nervous system (CNS) of living animals. Our technique could reveal the mechanisms underlying the immune responses and cell dynamics during neuroinflammation, CNS diseases, and also in the normal state.

Keywords

biomedical MRI; cell motility; diseases; neurophysiology; patient monitoring; cellular dynamics; central nervous system diseases; highly sensitive MR microimaging technique; immune responses; in vivo MRI monitoring; living animals; neuroimmunological assessments; neuroinflammation; ultrahigh-field magnetic resonance imaging; Biomedical monitoring; Crosstalk; Diseases; Immune system; Magnetic resonance imaging; Monitoring; microimaging; mouse; neuroimmunology; ultra high-field MRI (UHF-MRI);

fLanguage

English

Publisher

ieee

Conference_Titel

World Automation Congress (WAC), 2014

Conference_Location

Waikoloa, HI

Type

conf

DOI

10.1109/WAC.2014.6935939

Filename

6935939