Title :
In vivo MRI monitoring of inflammatory alterations and cellular dynamics in the central nervous system
Author :
Mori, Yuki ; Arima, Yasunobu ; Ting Chen ; Dasong Zhu ; Komai, Yutaka ; Murakami, Masaaki ; Yoshioka, Yoshichika ; Fujisawa, Tetsuya ; Kobashi, Syoji ; Hata, Yutaka
Author_Institution :
WPI Immunology Frontier Res. Center, Osaka Univ., Suita, Japan
Abstract :
This paper demonstrates the possibility of in vivo imaging for neuroimmunological assessments using ultra high-field magnetic resonance imaging (UHF-MRI). UHF-MRI provides a highly sensitive MR microimaging technique could be used to identify previously invisible pathologies and cellular dynamics in the central nervous system (CNS) of living animals. Our technique could reveal the mechanisms underlying the immune responses and cell dynamics during neuroinflammation, CNS diseases, and also in the normal state.
Keywords :
biomedical MRI; cell motility; diseases; neurophysiology; patient monitoring; cellular dynamics; central nervous system diseases; highly sensitive MR microimaging technique; immune responses; in vivo MRI monitoring; living animals; neuroimmunological assessments; neuroinflammation; ultrahigh-field magnetic resonance imaging; Biomedical monitoring; Crosstalk; Diseases; Immune system; Magnetic resonance imaging; Monitoring; microimaging; mouse; neuroimmunology; ultra high-field MRI (UHF-MRI);
Conference_Titel :
World Automation Congress (WAC), 2014
Conference_Location :
Waikoloa, HI
DOI :
10.1109/WAC.2014.6935939
