Feasibility study of paper-based surface enhanced Raman spectroscopy of tear fluids for onsite therapeutic drug monitoring

Author

Yokoyama, Moe ; Nishimura, Takahiro ; Yamada, Kenji ; Kido, Michiko ; Ohno, Yuko ; Sakurai, Yoshiaki ; Mita, Daiki ; Yamaguchi, Yoshinori ; Tamiya, Eiichi ; Nagakura, Toshiaki

Author_Institution

Grad. Sch. of Med., Osaka Univ., Suita, Japan

fYear

2014

fDate

3-7 Aug. 2014

Firstpage

474

Lastpage

477

Abstract

This paper discuss drug concentration measurement based on Raman spectroscopy of tear fluids with paper substrates for on-site therapeutic drug monitoring (TDM). We focus on tear fluids as alternative specimens to blood for minimally-invasive TDM. By using paper substrates, specimen collection and measurement based on surface enhanced Raman spectroscopy will be performed easily and inexpensively. In experiment, we fabricated paper-based substrate for surface enhanced Raman spectroscopy (SERS) of tear fluids and evaluated its surface. Scanning electron microscope images of them showed that gold nano-rods were adsorbed on the surface uniformly. This result implies that analysis of tear fluids with paper substrates would be realized with high sensitivity by SERS.

Keywords

adsorption; biomedical optical imaging; blood; drugs; gold; nanomedicine; nanorods; scanning electron microscopy; surface enhanced Raman scattering; Au; blood; drug concentration measurement; gold nanorod adsorption; minimally-invasive therapeutic drug monitoring; on-site therapeutic drug monitoring; paper-based surface enhanced Raman spectroscopy; scanning electron microscope images; tear fluid analysis; Biomedical imaging; Gold; Silicon; Spectroscopy; Time division multiplexing;

fLanguage

English

Publisher

ieee

Conference_Titel

World Automation Congress (WAC), 2014

Conference_Location

Waikoloa, HI

Type

conf

DOI

10.1109/WAC.2014.6936005

Filename

6936005