Film bulk acoustic resonator based biosensor for detection of cancer serological marker

Presented is a label-free biosensor based on a film bulk acoustic resonator (FBAR) to detect one of the cancer markers of alpha-fetoprotein (AFP). The FBAR consisted of a ZnO piezoelectric stack and works near 2.1 GHz. The monoclonal anti-AFP antibody was coated on the surface of the piezoelectric stack as the special bioprobe. Experimental results demonstrate that the FBAR based biosensor can detect AFP antigen successfully without chemical or fluorescent labelling. The minimum detectable AFP concentration of the proposed biosensor is 1 ng/ml with high selectivity. The advantages of this sensor, including the sample fabrication process, ease of detection method, low cost, high sensitive and high-throughput, mean that it has much promise in cancer diagnosis.