A Dual Modality System for Simultaneous Fluorescence and Positron Emission Tomography Imaging of Small Animals

Author

Liu, Shuangquan ; Zhang, Bin ; Wang, Xin ; Li, Lin ; Chen, Yan ; Liu, Xin ; Liu, Fei ; Shan, Baoci ; Bai, Jing

Author_Institution

Key Lab. of Nucl. Anal. Tech., Chinese Acad. of Sci., Beijing, China

Volume

58

Issue

1

fYear

2011

Firstpage

51

Lastpage

57

Abstract

A dual-modality imaging system for simultaneous fluorescence molecular tomography (FMT) and positron emission tomography (PET) of small animals has been developed. The system consists of a noncontact 360°-projection FMT module and a flat panel detector pair based PET module, which are mounted orthogonally for the sake of eliminating cross interference. The FMT images and PET data are simultaneously acquired by employing dynamic sampling mode. Phantom experiments, in which the localization and range of radioactive and fluorescence probes are exactly indicated, have been carried out to verify the feasibility of the system. An experimental tumor-bearing mouse is also scanned using the dual-modality simultaneous imaging system, the preliminary fluorescence tomographic images and PET images demonstrate the in vivo performance of the presented dual-modality system.

Keywords

biomedical imaging; flat panel displays; fluorescence; molecular biophysics; phantoms; positron emission tomography; tumours; FMT; PET; dual-modality imaging system; flat panel detector; fluorescence imaging; fluorescence molecular tomography; fluorescence probes; phantom; positron emission tomography; radioactive probes; tumor-bearing mouse; Dual-modality imaging; fluorescence molecular tomography; positron emission tomography;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/TNS.2010.2068310

Filename

5607336