Title :
A Dual Modality System for Simultaneous Fluorescence and Positron Emission Tomography Imaging of Small Animals
Author :
Liu, Shuangquan ; Zhang, Bin ; Wang, Xin ; Li, Lin ; Chen, Yan ; Liu, Xin ; Liu, Fei ; Shan, Baoci ; Bai, Jing
Author_Institution :
Key Lab. of Nucl. Anal. Tech., Chinese Acad. of Sci., Beijing, China
Abstract :
A dual-modality imaging system for simultaneous fluorescence molecular tomography (FMT) and positron emission tomography (PET) of small animals has been developed. The system consists of a noncontact 360°-projection FMT module and a flat panel detector pair based PET module, which are mounted orthogonally for the sake of eliminating cross interference. The FMT images and PET data are simultaneously acquired by employing dynamic sampling mode. Phantom experiments, in which the localization and range of radioactive and fluorescence probes are exactly indicated, have been carried out to verify the feasibility of the system. An experimental tumor-bearing mouse is also scanned using the dual-modality simultaneous imaging system, the preliminary fluorescence tomographic images and PET images demonstrate the in vivo performance of the presented dual-modality system.
Keywords :
biomedical imaging; flat panel displays; fluorescence; molecular biophysics; phantoms; positron emission tomography; tumours; FMT; PET; dual-modality imaging system; flat panel detector; fluorescence imaging; fluorescence molecular tomography; fluorescence probes; phantom; positron emission tomography; radioactive probes; tumor-bearing mouse; Dual-modality imaging; fluorescence molecular tomography; positron emission tomography;
Journal_Title :
Nuclear Science, IEEE Transactions on
DOI :
10.1109/TNS.2010.2068310
