• DocumentCode
    1360095
  • Title

    Simulating the immune system

  • Author

    Kleinstein, Steven H. ; Seiden, Philip E.

  • Author_Institution
    Dept. of Comput. Sci., Princeton Univ., NJ, USA
  • Volume
    2
  • Issue
    4
  • fYear
    2000
  • Firstpage
    69
  • Lastpage
    77
  • Abstract
    When a foreign substance (antigen) is introduced into our bodies, our immune system acts to eliminate that substance. This response is a complex process involving the collective and coordinated response of approximately 1012 cells, which is comparable to the number of synapses in the human brain. In an effort to fit detailed experimental observations into a comprehensive model of the immune system, computer simulations are just beginning to play a role. The approach that we describe uses a modified cellular automaton (or lattice gas). Although our automaton is much more complex than the automata usually considered by mathematicians and is not subject to analytical analysis by presently known methods, it has several advantages over traditional ODE models
  • Keywords
    biology computing; cellular automata; differential equations; digital simulation; antigen; computer simulations; immune system simulation; lattice gas; modified cellular automaton; ordinary differential equations; Biological system modeling; Cells (biology); Cloning; Computational modeling; Diseases; Genetic mutations; Immune system; Microorganisms; Peptides; Viruses (medical);
  • fLanguage
    English
  • Journal_Title
    Computing in Science & Engineering
  • Publisher
    ieee
  • ISSN
    1521-9615
  • Type

    jour

  • DOI
    10.1109/5992.852392
  • Filename
    852392