Development and in vivo Demonstration of CMOS-Based Multichip Retinal Stimulator With Simultaneous Multisite Stimulation Capability

Author

Tokuda, T. ; Takeuchi, Y. ; Sagawa, Y. ; Noda, T. ; Sasagawa, K. ; Nishida, K. ; Fujikado, T. ; Ohta, J.

Author_Institution

Grad. Sch. of Mater. Sci., Nara Inst. of Sci. & Technol., Nara, Japan

Volume

4

Issue

6

fYear

2010

Firstpage

445

Lastpage

453

Abstract

A complementary metal-oxide semiconductor (CMOS)-based multichip flexible neural stimulator for retinal prostheses was developed. The multichip retinal stimulator is capable of simultaneous multisite stimulation. An on-chip stimulation generator was implemented on the “unit chip,” which is the core device of the multichip retinal stimulator. The performance of the CMOS circuitry was characterized. A new device structure and packaging process was developed. The in vivo retinal stimulation on a rabbit´s retina was successfully performed and the multisite stimulation functionality was confirmed.

Keywords

CMOS integrated circuits; bioelectric phenomena; biomedical electronics; eye; integrated circuit packaging; neurophysiology; prosthetics; CMOS circuitry; complementary metal-oxide semiconductor circuitry; flexible neural stimulator; multichip retinal stimulator; multisite stimulation functionality; retinal prostheses; CMOS integrated circuits; Electrical stimulation; Implantable biomedical devices; Prosthetics; Retina; System-on-a-chip; Biomedical; complementary metal–oxide semiconductor (CMOS) biomedical device; neural stimulator; retinal prosthesis;

fLanguage

English

Journal_Title

Biomedical Circuits and Systems, IEEE Transactions on

Publisher

ieee

ISSN

1932-4545

Type

jour

DOI

10.1109/TBCAS.2010.2078508

Filename

5611631