Design and Evaluation of Three-Dimensional Electromagnetic Guide System for Magnetic Drug Delivery

A three-dimensional electromagnetic guide system for magnetic drug delivery was designed and theoretically analysed to demonstrate its feasibility. The system is mainly composed of one static Helmholtz coil and two kinetic racetrack coils that can generate compound gradient magnetic fields. In this paper, a Finite Element Model (FEM), relating to magnetic field distribution and the trajectories of the magnetic particles, has been built to investigate the performance of the magnet system. The calculation shows that an improved magnetic field is generated when different magnets work together. And the simplified simulation of particles trajectories suggests the magnetic micro-particles can be delivered and aggregated under the gradient magnetic field generated by the proposed system. The performed simulations reveal significant potential for the application in gene/drug therapy.