Noninvasive measurement of compliance of human leg arteries

Electrical impedance plethysmography has been evaluated for early detection of peripheral atherosclerosis. A pressure cuff was wrapped around the lower leg and the cuff pressure increased. Two circumferential electrodes glued in the middle of the cuff recorded with impedance pulse, from which the arterial pulse volume was calculated. The ratio of maximal arterial volume change to the pulse pressure was determined as a measure of maximal compliance C _p. Based on the data from 118 human subjects, C _p was found to correlate well with known cardiovascular risk factors. For example, C _p decreased on the average from 3.08 to 1.92 mu L/mmHg/cm in groups of subjects of increasing age from 22 to 70 yr. Subjects on a regular exercise program had an average value of 3.86, while those with proven peripheral vascular disease had a value of 0.70. In a related pathologic validation study on 15 monkeys fed a cholesterol-control diet, a good correlation was found between the limb peak compliance and morphometric data obtained from iliac and carotid arteries.